Changing the Treatment Paradigm in Cancer and Fibrotic Disease

learn more >

SELECTED PUBLICATIONS

Balanced Regulation of the CCN Family of Matricellular Proteins: A Novel Approach to the Prevention and Treatment of Fibrosis and Cancer.
Journal of Cell Communication and Signaling 9.4 (2015): 327–339.
PMC. Web. 28 Apr. 2016.

Patients with encapsulating peritoneal sclerosis have increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-β1, and vascular endothelial growth factor.
Abrahams AC, Habib SM, Dendooven A, Riser BL, van der Veer JW, Toorop RJ, Betjes MG, Verhaar MC, Watson CJ, Nguyen TQ, Boer WH.
PLoS One. 2014 Nov 10;9(11):e112050. Free PMC Article
Related citations
Select item 25193594

Treatment with the matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy.
Riser BL, Najmabadi F, Garchow K, Barnes JL, Peterson DR, Sukowski EJ. Am J Pathol. 2014 Nov;184(11):2908-21.

CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure.
Tsoutsman T, Wang X, Garchow K, Riser B, Twigg S, Semsarian C.
J Mol Cell Cardiol. 2013 Sep;62:164-78. doi: 10.1016/j.yjmcc.2013.05.019. Epub 2013 Jun 10. PMID: 23756156 [PubMed - in process]

Gadolinium-induced fibrosis is counter-regulated by CCN3 in human dermal fibroblasts: a model for potential treatment of nephrogenic systemic fibrosis.
Riser BL, Bhagavathula N, Perone P, Garchow K, Xu Y, Fisher GJ, Najmabadi F, Attili D, Varani J. J Cell Commun Signal. 2012 Jun;6(2):97-105. doi: 10.1007/s12079-012-0164-4. Epub 2012 May 31. PMID: 22648571 [PubMed] Free PMC Article

CCN2 (CTGF) gene polymorphism is a novel prognostic risk factor for cardiovascular outcomes in hemodialysis patients.
Cozzolino M, Biondi ML, Banfi E, Riser BL, Mehmeti F, Cusi D, Gallieni M.
Blood Purif. 2010;30(4):272-6. doi: 10.1159/000320706. Epub 2010 Nov 11. PMID: 21071938 [PubMed - indexed for MEDLINE] Free Article

CCN3/CCN2 regulation and the fibrosis of diabetic renal disease.
Riser BL, Najmabadi F, Perbal B, Rambow JA, Riser ML, Sukowski E, Yeger H, Riser SC, Peterson DR.
J Cell Commun Signal. 2010 Mar;4(1):39-50. doi: 10.1007/s12079-010-0085-z. Epub 2010 Feb 9. PMID: 20195391 [PubMed] Free PMC Article

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy.
Tam FW, Riser BL, Meeran K, Rambow J, Pusey CD, Frankel AH.
Cytokine. 2009 Jul;47(1):37-42. doi: 10.1016/j.cyto.2009.04.001. Epub 2009 May 5. PMID: 19409809 [PubMed - indexed for MEDLINE]

CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease.
Riser BL, Najmabadi F, Perbal B, Peterson DR, Rambow JA, Riser ML, Sukowski E, Yeger H, Riser SC. Am J Pathol. 2009 May;174(5):1725-34. doi: 10.2353/ajpath.2009.080241. Epub 2009 Apr 9. PMID: 19359517 [PubMed - indexed for MEDLINE] Free PMC Article

Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1.
Haydont V, Riser BL, Aigueperse J, Vozenin-Brotons MC.
Am J Physiol Cell Physiol. 2008 Jun;294(6):C1332-41. doi: 10.1152/ajpcell.90626.2007. Epub 2008 Apr 9. PMID: 18400984 [PubMed - indexed for MEDLINE] Free Article

TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis.
Cooker LA, Peterson D, Rambow J, Riser ML, Riser RE, Najmabadi F, Brigstock D, Riser BL.
Am J Physiol Renal Physiol. 2007 Jul;293(1):F157-65. Epub 2007 Mar 20. PMID: 17376761 [PubMed - indexed for MEDLINE] Free Article

Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report.
Riser BL, Cortes P, DeNichilo M, Deshmukh PV, Chahal PS, Mohammed AK, Yee J, Kahkonen D. Kidney Int. 2003 Aug;64(2):451-8. PMID: 12846740 [PubMed - indexed for MEDLINE]

Proposal for a unified CCN nomenclature.
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H. Mol Pathol. 2003 Apr;56(2):127-8. PMID: 12665631 [PubMed - indexed for MEDLINE] Free PMC Article

Can glomerular mRNAs in human type 1 diabetes be used to predict transition from normoalbuminuria to microalbuminuria?
Adler SG, Kang SW, Feld S, Cha DR, Barba L, Striker L, Striker G, Riser BL, LaPage J, Nast CC.
Am J Kidney Dis. 2002 Jul;40(1):184-8. PMID: 12087577 [PubMed - indexed for MEDLINE]

Glomerular mRNAs in human type 1 diabetes: biochemical evidence for microalbuminuria as a manifestation of diabetic nephropathy.
Adler SG, Kang SW, Feld S, Cha DR, Barba L, Striker L, Striker G, Riser BL, LaPage J, Nast CC.
Kidney Int. 2001 Dec;60(6):2330-6. Erratum in: Kidney Int 2002 Mar;61(3):1197. PMID: 11737607 [PubMed - indexed for MEDLINE] Free Article

Connective tissue growth factor and its regulation: a new element in diabetic glomerulosclerosis.
Riser BL, Cortes P.
Ren Fail. 2001 May-Jul;23(3-4):459-70. PMID: 11499561 [PubMed - indexed for MEDLINE]

Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis.
Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG.
J Am Soc Nephrol. 2000 Jan;11(1):25-38. PMID: 10616837 [PubMed - indexed for MEDLINE] Free Article

TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain.
Riser BL, Ladson-Wofford S, Sharba A, Cortes P, Drake K, Guerin CJ, Yee J, Choi ME, Segarini PR, Narins RG.
Kidney Int. 1999 Aug;56(2):428-39. PMID: 10432381 [PubMed - indexed for MEDLINE] Free Article

Mechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-beta.
Riser BL, Cortes P, Yee J, Sharba AK, Asano K, Rodriguez-Barbero A, Narins RG.
J Am Soc Nephrol. 1998 May;9(5):827-36. PMID: 9596080 [PubMed - indexed for MEDLINE] Free Article

Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells.
Riser BL, Cortes P, Heilig C, Grondin J, Ladson-Wofford S, Patterson D, Narins RG.
Am J Pathol. 1996 Jun;148(6):1915-23. PMID: 8669477 [PubMed - indexed for MEDLINE] Free PMC Article

Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.
Riser BL, Cortes P, Zhao X, Bernstein J, Dumler F, Narins RG.
J Clin Invest. 1992 Nov;90(5):1932-43. PMID: 1430216 [PubMed - indexed for MEDLINE] Free PMC Article

© BLR Bio, L.L.C. | 313 54th Street, Kenosha, WI, USA, 53140 | info@BLRbio.com

Latest News

May 2016
"Dr. Bruce Riser, CEO of BLR Bio, was an invited speaker on Peptide Discovery, Preclinical and Clinical presented at the TIDES Oligonucleotide and Peptide Therapeutics Conference, at Long Beach. See selected pre-interview."

April 2016
"BLR Bio was selected as one of the top 50 emerging biotechnology companies to present at the MedCity INVEST, Health Tech Showcase in Chicago April 10-12."

see news archives »

Publications

April 2016
Balanced Regulation of the CCN Family of Matricellular Proteins: A Novel Approach to the Prevention and Treatment of Fibrosis and Cancer.
Journal of Cell Communication and Signaling 9.4 (2015): 327–339.
PMC. Web. 28 Apr. 2016.

more publications »